Mushroom Synergy 10 is a raspberry-flavored gummy dietary supplement. The ingredient list names mushroom extract from ten species: Maitake, Shiitake, Lion's Mane, Reishi, Cordyceps, Chaga, Turkey Tail, White Button Mushroom, Black Fungus and Royal Sun Mushroom, described as fruiting body 10:1 extracts. Each serving of 2 gummies (30 servings per container) provides 250 mg of the mushroom extract blend in total; the label does not give the amount of each extract. A serving also provides 20 calories and 5 g of sugars, all of it added sugars (10% of the Daily Value).*
Human studies exist for only some of these mushrooms, they tested other preparations and mostly much larger amounts than this gummy provides, and no study of this gummy was found. The studies described below are about individual mushrooms, not about this product. If the 250 mg blend were split equally, each of the ten extracts would be about 25 mg per serving; a 10:1 extract is normally made from about 10 parts of mushroom per part of extract, so that is about 250 mg of mushroom each (the label does not say whether the ratio is on a fresh or dried basis).*
SCIENCE
Lion's Mane: In a 16-week trial in 30 adults aged 50 to 80 with mild cognitive impairment, those taking Lion's Mane dry powder tablets (about 3 g a day) scored higher than those taking placebo on a cognitive scale at weeks 8, 12 and 16, and scores fell after intake stopped; the first author's affiliation is a mushroom company. A 12-week trial of a supplement made from Lion's Mane fruiting body found a significant improvement on only one of three cognitive tests. A 41-person pilot trial in healthy young adults reported faster responses on one task after a single dose, a non-significant trend toward lower stress after 28 days, and some null findings. These trials were small and used much more than this gummy provides: about 3 g a day of dry powder in the first trial and 1.8 g a day in the pilot trial, compared with 250 mg of extract blend for all ten mushrooms in a 2-gummy serving. Mori 2009 · Saitsu 2019 · Docherty 2023
Reishi: In an 84-day randomized trial in healthy adults aged 18 to 55, a Reishi beta-glucan was associated with higher counts of CD3+, CD4+ and CD8+ T cells and natural killer cells, and higher IgA, than placebo, with no significant change in kidney or liver markers. These are laboratory measures, and the abstract does not report whether they changed infections or health. A Cochrane review of five trials in people with cancer concluded that the evidence did not justify using Reishi as a first-line cancer treatment, and a Cochrane review in people with type 2 diabetes did not support its use for cardiovascular risk factors. The abstract of the Reishi beta-glucan trial does not give the dose, and the label does not say how much Reishi the gummy contains. Chen 2023 · Jin 2016 · Klupp 2015
Cordyceps: In a 12-week pilot trial in 20 healthy people aged 50 to 75, Cs-4 (a Cordyceps sinensis product) at 333 mg three times a day was followed by higher metabolic and ventilatory thresholds on an exercise test, with no significant change on placebo and no change in VO2 max in either group. The label does not name the Cordyceps species, and the 999 mg a day used in the trial compares with about 25 mg of Cordyceps extract if the 250 mg blend were split equally among the ten mushrooms. Chen 2010
Shiitake, White Button and Turkey Tail: In a 4-week trial in 52 healthy adults aged 21 to 41, eating 5 or 10 g of whole dried shiitake mushrooms a day was followed by higher ex vivo proliferation of two types of immune cell; whole-mushroom amounts cannot be compared with an extract in a gummy. In adults aged 60 and over, 5 g a day of White Button mushroom powder for 8 weeks did not significantly affect the response to influenza vaccination. A Cochrane review of seven trials of Turkey Tail (Coriolus) extract in people with colorectal cancer rated the evidence for effects on treatment side effects as very low certainty. The Shiitake (5 to 10 g) and White Button (5 g) amounts in these trials are far above the roughly 25 mg of extract each that a 2-gummy serving would give if the blend were split equally. Trials of the forms and amounts used in this gummy were not found for these mushrooms, Maitake, Black Fungus or Royal Sun Mushroom. Dai 2015 · Zwaan 2026 · Pilkington 2022
Sugars: The label shows 20 calories, 5 g of total carbohydrate (2% of the Daily Value) and 5 g of sugars per serving of 2 gummies, all of them added sugars (10% of the Daily Value); the ingredients list glucose syrup, sugar and dextrose. A 2022 systematic review of epidemiological studies found lower tooth decay when sugars intake was under 10% of energy; it did not study gummy supplements, but sugars from a gummy count toward daily intake. People with diabetes, or who are limiting sugar or prone to tooth decay, can ask a doctor, pharmacist or dentist whether it suits them. Moores 2022
Cautions: Chaga contains oxalate, and case reports describe kidney injury, including kidney failure, after regular use of chaga powder; the label lists Chaga extract within the 250 mg blend (about 25 mg if split equally, against the several grams of powder a day in the case reports) and does not state its oxalate content. A report from Thailand describes fatal fulminant hepatitis associated with Reishi powder in a patient who had also taken other therapeutic agents, and a 2023 report describes acute hepatitis in a man who had taken Reishi powder and alcohol. The label names the Royal Sun mushroom as Agaricus subrufescens, a species also sold as Agaricus blazei; a 2025 case report describes liver injury in a woman taking a mushroom powder of Agaricus blazei and Lion's Mane (three capsules a day), and the authors linked it mainly to Agaricus blazei. Ask a doctor or pharmacist before use if you have kidney or liver problems, a mushroom allergy or an autoimmune condition, are pregnant or breastfeeding, or take blood thinners, diabetes medicines or immunosuppressants. Kikuchi 2014 · Lee 2020 · Kwon 2022 · Wanmuang 2007 · Guedikian 2023 · Strobbe 2025
Evidence Rating★★★★★Very limited evidence · Human trials exist for only some of the ten mushrooms, are mostly small and used other preparations at much larger amounts than 250 mg of blend per serving; no trial of this gummy was found
✓ Third-party tested · GMP-certified manufacturing facility (NSF International) · See testing standards ›
Ingredients: Mushroom extract (Maitake, Shiitake, Lion's Mane, Reishi, Cordyceps, Chaga, Turkey Tails, White Button Mushroom, Black Fungus, Royal Sun Mushroom — all Fruiting Body 10:1 Extract), glucose syrup, sugar, dextrose, pectin, citric acid, natural raspberry flavor, sodium citrate, purple carrot juice concentrate, palm oil (contains carnauba wax).
Flavor: Raspberry | Manufacturer Country: USA | Product Amount: 60 gummies | Gross Weight: 0.3lb (136g)
Suggested Use: 2 gummies daily or as directed by a healthcare professional.
Warning: Keep out of reach of children. Do not use if the safety seal is damaged or missing. Store in a cool, dry place.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
