The Kasivit Evidence Standard

🔬 Evidence Standard

How We Choose What We Sell

Every Kasivit product must clear a strict evidence bar before it earns a place on our shelves. Here is exactly what that bar looks like — in plain English and in the scientific language that matters.

Why most supplement brands can’t show you this page

The supplement industry is largely unregulated before products reach shelves. Brands can list almost any ingredient, make almost any marketing claim, and never disclose whether the dose in their capsule matches the dose studied in research. We think that’s a problem — and this page is our answer to it.

Our commitment: Every active ingredient in every Kasivit product is supported by peer-reviewed human clinical evidence, dosed to match that evidence, and described using only language that is legally and scientifically accurate under FDA dietary supplement regulations.

The Evidence Hierarchy

Not all research is equal. Scientists use a ranked system — called the evidence hierarchy — to evaluate the reliability of different study types. We use the GRADE framework (Grading of Recommendations, Assessment, Development and Evaluations), the same system used to write clinical guidelines.

T1

Systematic Reviews & Meta-Analyses of RCTs — Highest quality

A systematic review is a structured analysis of all available studies on a specific question. A meta-analysis pools data from multiple Randomised Controlled Trials (RCTs) to produce a single, statistically powerful estimate of effect. This is the gold standard of evidence — and our preferred citation type for primary product claims.

T2

Randomised Controlled Trials (RCTs) in Humans — High quality

In an RCT, participants are randomly assigned to receive either the supplement or a placebo. Randomisation controls for confounding factors and allows researchers to draw causal conclusions. Kasivit requires at least one RCT for any primary health claim.

T3

Observational / Cohort Studies — Moderate quality

These studies follow groups of people over time without assigning a treatment. They can show associations but cannot prove causation. Kasivit uses Tier 3 evidence only for secondary or exploratory claims — never as the sole basis for a primary claim.

T4

Animal Studies (In Vivo) — Low quality for human claims

Studies conducted in living animals. Useful for understanding biological mechanisms, but many findings in animals do not replicate in humans. Kasivit never uses animal research as the primary evidence for a health claim.

T5

In-Vitro / Cell Culture Studies — Lowest quality

Studies conducted in cells in a laboratory dish. Important for early-stage research, but provide no reliable evidence about what happens in the human body at a given dose. We never cite in-vitro studies as evidence for a product claim.

What this means for you: When you see a Kasivit product, its primary health benefit is backed by at least one human RCT (Tier 2) or a systematic review / meta-analysis (Tier 1). We will always tell you which.

What Every Kasivit Product Must Pass

Before a product is listed on kasivit.com, it must satisfy three inclusion criteria and clear four disqualifying red flags.

📋

Named, Verifiable Citations

Every health claim must be supported by a named, peer-reviewed study with a specific author list, journal, publication year, and DOI or PubMed ID. “Studies show…” without a citation does not meet this standard.

🔬

Tier 1 or Tier 2 Evidence on the Primary Claim

The main health benefit must be supported by at least one Randomised Controlled Trial in humans, or a systematic review / meta-analysis of RCTs. Animal studies and cell studies alone do not qualify.

⚖️

Dose Matches the Studied Dose

The amount of each active ingredient per serving must match the dose used in the supporting clinical trial. A product containing 50 mg of an ingredient studied at 500 mg does not pass this check.

🚩

No Hidden Proprietary Blends

A proprietary blend that lists only a total weight — without disclosing individual ingredient amounts — makes independent dose verification impossible. If we cannot verify the dose, we will not carry the product.

🚩

No Exclusively Manufacturer-Funded Evidence

Research funded solely by the ingredient manufacturer introduces a documented bias toward positive results. We require at least one independent or government-funded study before relying on the evidence base.

🚩

No Disease Claims

Under FDA regulations, dietary supplements cannot claim to diagnose, treat, cure, or prevent a disease. Claims like “treats obesity” or “reverses type 2 diabetes” are illegal for supplements. We never make them.

What We Can — and Cannot — Say

FDA regulations distinguish between two types of claims for dietary supplements. Understanding the difference helps you spot honest brands from misleading ones.

Claim Type Status Example Kasivit Position
Structure/Function claimSays a nutrient supports a normal body function ✅ Legal “Supports healthy blood sugar levels”
“Promotes fat metabolism”		 We use these when backed by Tier 1 or 2 evidence, always with the required FDA disclaimer.
Unsubstantiated claimMakes a benefit claim without evidence ⚠ Legally grey “Melts fat fast” (no evidence cited) We never make unsubstantiated claims. Every benefit we describe is linked to a specific study.
Disease claimClaims to treat, cure, reverse, or prevent a disease 🚫 Illegal for supplements “Treats obesity”
“Reverses type 2 diabetes”		 We never make disease claims. If we see them in partner content, we address it immediately.

The required FDA disclaimer: Every structure/function claim we make is accompanied by — “These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.”

What This Looks Like on a Product Page

Every Kasivit product page includes the following, so you can verify our claims yourself:

  • The primary health benefit — written as a substantiated structure/function claim
  • The key ingredients with individual doses disclosed
  • An evidence summary citing the specific study type (e.g., “In a 2022 RCT published in Nutrients…”)
  • A numbered reference list in Vancouver format with DOI or PubMed links
  • The full FDA disclaimer

If you read a Kasivit product page and find a claim without a citation, or a dose that doesn’t match the study, we want to know. Email us at contact@kasivit.com.

See the Standard in Action

Browse our products and read the evidence behind each formulation — every claim, every dose, every citation.

Shop Evidence-Based Products