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Kasivit

Kasivit L-Glutamine Powder - Unflavored

Name: Kasivit L-Glutamine Powder - Unflavored
Brand: Kasivit
SKU: KV-GLUT-98
Price: 29.99 USD
Availability: InStock

Unflavored L-glutamine powder: 3.15 g of L-glutamine per scoop (5cc / 3.3 g), with silicon dioxide. 98 g (3.5 oz).

💊Mix one (1) scoop (5cc / 3.3g) with 6–8 oz (177–237ml) of water or preferred beverage daily. Do not exceed recommended dose. Store in a cool, dry place.

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Key Benefits

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Single Active Ingredient

Each scoop (5cc / 3.3 g) provides 3.15 g of L-glutamine, with silicon dioxide as the only other ingredient in the supplier's ingredient list. It is an unflavored powder to mix with 6-8 oz (177-237 ml) of water or a beverage once daily, per the suggested use.

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Gut: Studied Mostly in Specific Conditions

An 8-week trial in adults with post-infectious, diarrhea-predominant IBS and increased intestinal permeability used 15 g of glutamine per day and reported improved symptoms and permeability versus placebo. A meta-analysis of 10 trials found no significant overall effect on permeability. One scoop provides 3.15 g. Evidence in healthy adults is limited.

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Muscle Recovery: Limited and Mixed Evidence

One crossover trial of 16 adults found faster recovery of peak torque and lower soreness with glutamine at 0.3 g per kg per day (about 21 g for a 70 kg adult) after eccentric exercise. A systematic review of six trials found insufficient data on glutamine and muscle strength. The doses studied were higher than one scoop.

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Immune Function: Evidence Is Mixed

Immune cells use glutamine. In athletes, glutamine feeding did not prevent post-exercise changes in several aspects of immune function, and a review found little support from well-controlled studies in healthy, well-nourished people. One small study reported fewer self-reported infections after glutamine drinks.

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Who Should Ask a Doctor First

Ask a doctor before use if you have kidney disease, liver disease or cirrhosis, a seizure disorder, cancer or diabetes, are pregnant or nursing, or take regular medicines. Glutamine is not for use in intensive care unless prescribed by the care team: in one large trial it was associated with higher mortality.

✅This product is for you if…

You want a single-ingredient L-glutamine powder with 3.15 g per scoop (silicon dioxide is the only other listed ingredient)
You prefer an unflavored powder to mix with water or a beverage once daily
You have checked with your doctor or pharmacist if you have a medical condition or take regular medicines

⚠️Consult your healthcare provider if…

You have kidney disease or reduced kidney function: in older adults taking a high dose, blood urea nitrogen and creatinine rose and kidney function estimates fell. Ask your doctor first
You have liver disease or cirrhosis: ask your doctor first (an oral glutamine load is used as a test of ammonia handling in cirrhosis)
You have a seizure disorder or epilepsy: ask your doctor first (oral glutamine increased seizure severity in a rat model; relevance to people is not established)
You have cancer or are having cancer treatment: ask your oncologist first
You have diabetes or take glucose-lowering medicines: ask your prescriber or pharmacist first (a trial in type 2 diabetes reported modestly lower HbA1c)
You are hospitalized or in intensive care: use only if the care team prescribes it (glutamine was associated with higher mortality in critically ill adults with multiorgan failure)
You are pregnant or nursing: consult your doctor before use (supplier warning)
You are under 18: not intended for children under 18 (supplier warning)
You take prescription medicines or have a known medical condition: ask your doctor or pharmacist first
You have persistent bloating, diarrhea or a change in bowel habit: see a doctor for a diagnosis; "leaky gut" is not a diagnosis
Do not use if the safety seal is damaged or missing
Never stop or change a prescribed medicine without asking your prescriber

Formula

Ingredients & Dosages

Serving size: Mix one (1) scoop (5cc / 3.3g) with 6–8 oz (177–237ml) of water or preferred beverage daily. Do not exceed recommended dose. Store in a cool, dry place.

Ingredient	Amount Per Serving	Purpose
L-Glutamine	3150 mg	Amino acid (3.15 g per scoop)
Silicon Dioxide		Anti-caking agent — ensures powder flows freely and mixes evenly

† Daily Value not established. Other ingredients: Silicon Dioxide.

Science

Clinical Evidence

Published research relevant to this product. These studies were generally not conducted on this specific product.

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In an 8-week randomized, double-blind, placebo-controlled trial, 106 adults who completed it (54 glutamine, 52 placebo) with post-infectious, diarrhea-predominant irritable bowel syndrome and increased intestinal permeability took glutamine 5 g three times a day (15 g per day). 79.6% of the glutamine group versus 5.8% of the placebo group reached the primary endpoint (a drop of 50 or more points on the IBS Severity Scoring System); permeability was normalized in the glutamine group; no serious adverse events were observed. The authors called for larger trials.

Zhou Q et al. Gut. 2019;68(6):996-1002. ↗

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A systematic review and meta-analysis of 10 placebo-controlled trials (352 participants with different health conditions) found that glutamine supplementation did not significantly affect intestinal permeability overall; a significant reduction appeared only in a subgroup of trials using doses above 30 g per day.

Abbasi F et al. Amino Acids. 2024;56(1):60. ↗

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A review described glutamine as the most abundant free amino acid in the human body and a major substrate used by intestinal cells; in gut physiology it promotes enterocyte proliferation and regulates tight junction proteins. As glutamine stores are depleted in severe metabolic stress such as trauma, sepsis and inflammatory bowel disease, supplementation has been examined in patients.

Kim MH, Kim H. Int J Mol Sci. 2017;18(5):1051. ↗

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A review of gastroenterology literature states that leaky gut syndrome is popularized in the lay literature but is not currently accepted as a formal medical diagnosis, and that no validated test exists to diagnose it.

Lacy BE et al. Gastroenterol Hepatol (N Y). 2024;20(5):264-272. ↗

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A review reported that glutamine is an essential nutrient for lymphocyte proliferation and cytokine production in laboratory studies and that it can become essential during catabolic situations, but that it is currently difficult to determine whether glutamine supplementation should be recommended in ill or critically ill people, after trauma or sepsis, or in exhausted athletes.

Cruzat V et al. Nutrients. 2018;10(11):1564. ↗

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In a double-blind, placebo-controlled crossover study of 16 healthy adults, glutamine at 0.3 g per kg of body weight per day for 72 hours was followed by greater relative peak torque at 180 degrees per second (91% vs 86% at 72 hours) and lower muscle soreness ratings at 24, 48 and 72 hours after eccentric knee-extension exercise than placebo. The dose is several times that of one scoop of this product.

Legault Z et al. Int J Sport Nutr Exerc Metab. 2015;25(5):417-26. ↗

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A systematic review of six trials of oral glutamine in adults with muscle strength deficits during exercise programs found that studies of glutamine alone did not suggest differences between groups (apart from perceived muscle weakness), and concluded that data on glutamine and muscle strength are insufficient. No meta-analysis was possible.

Hernandez Valencia SE et al. Nutr Hosp. 2015;32(4):1443-53. ↗

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A review of glutamine dosing in exercise and sport found that glutamine feeding that kept plasma glutamine constant did not prevent post-exercise changes in several aspects of immune function, and that the suggested reasons for taking glutamine supplements (immune support, increased glycogen synthesis, anticatabolic effect) have received little support from well-controlled studies in healthy, well-nourished humans. It also reported no harm in one study in which athletes consumed 28 g of glutamine daily for 14 days.

Gleeson M. J Nutr. 2008;138(10):2045S-2049S. ↗

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In a study of 151 athletes, the percentage reporting no infections in the 7 days after exercise was higher in the group given glutamine drinks (81%, n = 72) than in the placebo group (49%, n = 79). Infections were self-reported by questionnaire; this 1996 study is small and the abstract does not describe blinding.

Castell LM et al. Eur J Appl Physiol Occup Physiol. 1996;73(5):488-90. ↗

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A risk assessment found strong evidence for the absence of adverse effects in healthy adults at glutamine intakes up to 14 g per day, while stating that data for intakes above these levels are not sufficient to conclude long-term safety. The author is affiliated with the Council for Responsible Nutrition, a supplement-industry trade association.

Shao A, Hathcock JN. Regul Toxicol Pharmacol. 2008;50(3):376-99. ↗

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In a crossover trial of 30 long-term-care residents (mean age 69), glutamine at 0.5 g per kg per day for 14 days produced no adverse clinical effects or clinically significant laboratory changes, but plasma urea nitrogen and creatinine rose and estimated glomerular filtration rate fell by 13.3%; the authors said this calls for rigorous monitoring of kidney function with oral glutamine at this dose.

Galera SC et al. Nutrition. 2010;26(4):375-81. ↗

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A review of the renal safety of amino acid supplements reported that short-term (20-30 g within a few hours) and longer-term (0.1 g per kg four times daily for 2 weeks) glutamine supplementation in healthy athletes was associated with no significant adverse effects, but that glutamine can cause glomerulosclerosis and serum creatinine elevation in the setting of diabetic nephropathy.

Davani-Davari D et al. J Ren Nutr. 2019;29(3):221-234. ↗

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In 238 patients with cirrhosis, an oral glutamine challenge (blood ammonia measured at baseline and 60 minutes after the load) was used as a test of ammonia metabolism; an impaired response identified patients at higher risk of hepatic encephalopathy.

Ampuero J et al. Liver Int. 2020;40(4):921-930. ↗

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In a randomized, placebo-controlled trial of 1,223 critically ill adults with multiorgan failure who were receiving mechanical ventilation, glutamine given intravenously and by tube did not improve clinical outcomes and was associated with higher in-hospital and 6-month mortality.

Heyland D et al. N Engl J Med. 2013;368(16):1489-97. ↗

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A review of glutamine supplementation in cancer concluded that its use needs careful consideration of potential interactions with ongoing treatment regimens and of the balance between supporting normal cellular function and promoting tumorigenesis.

Muranaka H et al. Cancers (Basel). 2024;16(5):1057. ↗

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In a randomized crossover study of 13 adults with well-controlled type 2 diabetes taking metformin, glutamine 15 g twice daily for 4 weeks (with or without sitagliptin) modestly decreased HbA1c and fructosamine and was associated with mild plasma volume expansion; blood urea increased, while creatinine and estimated glomerular filtration rate were unchanged.

Samocha-Bonet D et al. PLoS One. 2014;9(11):e113366. ↗

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In rats, drinking glutamine-supplemented water did not change seizure frequency but increased the proportion of convulsive seizures during the first three days in a model of mesial temporal lobe epilepsy, which the authors said indicates a potential role of glutamine in seizure propagation. This is an animal study; its relevance to people is not established.

Dhaher R et al. Nutr Neurosci. 2022;25(1):64-69. ↗

🔬 All studies referenced are peer-reviewed and published in indexed medical journals. This information is for educational purposes and does not constitute medical advice.

Kasivit L-Glutamine Powder is an unflavored dietary supplement. Each scoop (5cc / 3.3 g) provides 3.15 g of L-glutamine; the only other ingredient listed by the supplier is silicon dioxide. L-glutamine is the most abundant free amino acid in the human body and a major substrate used by intestinal cells. Kim 2017 Studies of glutamine supplements show limited and mixed results in healthy adults, and no study of this product is cited here.

Gut: In an 8-week trial of 106 adults who completed it, all with post-infectious, diarrhea-predominant irritable bowel syndrome and increased intestinal permeability, 5 g of glutamine three times a day (15 g per day) improved IBS symptom scores and permeability compared with placebo, with no serious adverse events; the authors called for larger trials. A meta-analysis of 10 placebo-controlled trials (352 participants) in different groups found no significant overall effect of glutamine on intestinal permeability; a significant reduction appeared only in a subgroup using more than 30 g per day. One scoop of this product provides 3.15 g. "Leaky gut" is not currently accepted as a formal medical diagnosis and no validated test exists, so see a doctor for persistent digestive symptoms. Zhou 2019 · Abbasi 2024 · Lacy 2024

Muscle recovery: In a crossover trial of 16 healthy adults after eccentric knee exercise, glutamine at 0.3 g per kg of body weight per day (about 21 g for a 70 kg adult, several times the amount in one scoop) was followed by faster recovery of peak torque and lower soreness ratings than placebo over 72 hours. A systematic review of six trials in adults with muscle strength deficits concluded that data on glutamine and muscle strength were insufficient. Legault 2015 · Hernández Valencia 2015

Immune function: Immune cells use glutamine, but in athletes, glutamine feeding that kept plasma glutamine constant did not prevent post-exercise changes in several aspects of immune function, and a review found little support from well-controlled studies in healthy, well-nourished people for taking glutamine to support the immune system. In one 1996 study of 151 athletes, more of those who drank glutamine after exercise reported no infections in the next 7 days (81% vs 49%); infections were self-reported by questionnaire. Gleeson 2008 · Castell 1996

Safety: Short-term studies in healthy adults have not linked glutamine intakes up to 14 g per day to adverse effects, but data above that are not enough to judge long-term safety. In a trial of 1,223 critically ill adults with multiorgan failure, glutamine given intravenously and by tube was associated with higher in-hospital and 6-month mortality. Ask a doctor first if you have kidney disease, liver disease or cirrhosis, a seizure disorder, cancer or diabetes, or take regular medicines. Shao 2008 · Heyland 2013*

Ingredients: L-Glutamine (3.15g), Silicon Dioxide.

Manufacturer's country: USA

Product amount (oz/lbs/g): 3.5 oz / 0.2 lbs / 98g

Gross weight (oz/lbs/g): 4.9 oz / 0.3 lbs / 139g

Suggested use: As a dietary supplement, adults mix one (1) scoop with 6-8 oz (177-237ml) of water or favorite beverage daily.

CAUTION: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with known medical conditions should consult a physician before using this or any dietary supplement.

KEEP OUT OF THE REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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