Ashwagandha Plus is a dietary supplement. The supplier's ingredient list gives KSM-66® ashwagandha extract (standardized to 5% withanolides) 600 mg, L-arginine 300 mg, maca root powder 150 mg, Panax ginseng root powder 100 mg, shatavari root powder 50 mg, vitamin D3 20 mcg, vitamin B6 2.5 mg and vitamin B12 (as methylcobalamin) 25 mcg, in vegetarian HPMC capsules. Adults take two (2) capsules daily.
Studies of ashwagandha extracts report lower cortisol and a small effect on sleep, while results for stress scores, testosterone and fatigue are mixed; evidence for ginseng, maca, L-arginine and shatavari is limited. These studies tested the ingredients on their own, and no study of this formula is cited on this page. Ashwagandha has been linked to rare cases of liver injury and to changes in thyroid hormones, so ask a doctor or pharmacist first if you take medicines or have a medical condition.*
Evidence Rating
★★★★★
Limited evidence · Ashwagandha extract has been studied in several trials (results mixed, certainty low); evidence for the other ingredients is limited; no study of this formula is cited
✓ Third-party tested · GMP-certified manufacturing facility (UL Solutions) · See testing standards ›
Science behind this product
The studies below tested single ingredients, mostly as extracts, usually in small or short trials. They did not test this formula.
Ashwagandha: stress, cortisol and sleep
A meta-analysis of 12 randomized trials (1,002 participants) found lower anxiety and stress scores with ashwagandha extract than with placebo, with low certainty of evidence. Another meta-analysis found lower cortisol but no significant effect on perceived stress scores. A meta-analysis of 5 trials (400 participants) found a small improvement in overall sleep, larger in adults with insomnia, at 600 mg a day or more and with treatment of 8 weeks or longer.
Akhgarjand 2022 · Albalawi 2025 · Cheah 2021
Ashwagandha: energy, testosterone and sexual function
In 57 overweight men aged 40-70 with mild fatigue, 8 weeks of an ashwagandha extract was associated with a greater rise in testosterone and DHEA-S than placebo, but there were no significant differences between groups in fatigue, vigor or sexual well-being. A 2021 systematic review of herbs and testosterone in men found positive effects for ashwagandha extracts but noted small samples and varied doses and extracts; a 2026 meta-analysis found testosterone rose in men but not in women. Two 8-week placebo-controlled trials in healthy men aged 30-50 (76 and 100 participants), each using 300 mg of ashwagandha root extract twice daily, reported higher sexual desire scores than placebo. In a trial of 50 healthy athletic adults, KSM-66 ashwagandha was followed by a greater rise in VO2 max than placebo.
Lopresti 2019 · Smith 2021 · Fornalik 2026 · Khanna 2026 · Mutha 2025 · Choudhary 2015
Panax ginseng, maca, shatavari and L-arginine
A meta-analysis of 19 randomized trials found no significant reduction in fatigue with ginseng overall, with small effects in some subgroups, and a Cochrane review found a trivial effect of ginseng on erectile dysfunction. A systematic review of four trials of maca found limited evidence for improving sexual function. One 8-week trial in 70 women with low libido used 300 mg of shatavari root extract, a larger amount than the 50 mg of shatavari powder listed for this product. A randomized trial of L-arginine (3 g three times daily) after a heart attack found no benefit and possibly higher mortality, and its authors advised against L-arginine after acute myocardial infarction.
Li 2023 · Lee 2021 · Shin 2010 · Satla 2026 · Schulman 2006
Safety
A 2026 systematic review of 23 randomized trials (2,317 healthy adults) of standardized, root-only ashwagandha extracts at 125-600 mg a day for up to 180 days reported no serious adverse events attributable to the extract, with limited data beyond 180 days. Separately, case reports describe liver injury (often with jaundice and itching) usually starting 2-12 weeks after beginning ashwagandha supplements; most people recovered after stopping, but one liver transplant and three deaths in people with cirrhosis have been reported. Reviews identify pregnant women, people with thyroid disorders and people with liver or kidney problems as higher-risk groups. A meta-analysis found a modest rise in thyroxine (T4) with ashwagandha. For Panax ginseng, possible interactions have been reported with warfarin, phenelzine and alcohol. Stop use and seek medical advice if you notice yellowing of the skin or eyes, itching, dark urine or nausea with tiredness.
Coope 2026 · Björnsson 2020 · McIntyre 2026 · Li 2026 · Fornalik 2026 · Coon 2002
Ingredients: Vitamin D3 (as Cholecalciferol) (20 mcg), Vitamin B6 (as Pyridoxine Hydrochloride) (2.5 mg), Vitamin B12 (as Methylcobalamin 1%) (25 mcg), KSM-66® Ashwagandha Extract (standardized to 5% Withanolides) (600 mg), L-Arginine (300 mg), Maca Root Powder (Lepidium meyenii) (root) (150 mg), Panax Ginseng Powder (root) (100 mg), Shatavari Powder (Asparagus racemosus) (root) (50 mg), HPMC (vegetable capsule).
Manufacturer's country: USA
Product amount: 60 capsules / 1.6 oz / 0.1 lbs / 44 g
Gross weight (oz/lbs/g): 2.56 oz / 0.16 lbs / 73 g
Suggested use: As a dietary supplement, adults take two (2) capsules daily. For best results, take with 6-8 oz (177-237ml) of water or as directed by healthcare professional.
Warning: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with known medical conditions should consult a physician before using this or any dietary supplement. KEEP OUT OF THE REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
