Vitamin D3 + K2 (MK-7) with calcium and BioPerine® | 60 Capsules
What this supplement contains
This dietary supplement combines vitamin D3 (cholecalciferol), vitamin K2 as MK-7 (menaquinone), calcium (as calcium carbonate) and BioPerine® black pepper fruit extract in a hypromellose (vegetable) capsule. Per the Supplement Facts label, one capsule (one serving; 60 servings per container) provides calcium (as calcium carbonate) 210 mg (16% of the Daily Value), vitamin D3 (cholecalciferol) 125 mcg (5,000 IU; 625% of the Daily Value), vitamin K2 (MK-7, as menaquinone) 100 mcg and BioPerine® (black pepper fruit extract) 5 mg. The other ingredients are microcrystalline cellulose and hypromellose (vegetable capsule). Take 1 capsule daily. The 125 mcg (5,000 IU) of vitamin D3 in one capsule is above the adult Tolerable Upper Intake Level of 100 mcg (4,000 IU) a day from all sources set by the US National Academy of Medicine. Ask a doctor or pharmacist before use, especially if you take other vitamin D, calcium or vitamin K supplements or warfarin, or have kidney disease, high blood calcium or kidney stones, and do not combine this product with other vitamin D products.
Vitamin D3 and calcium
Vitamin D helps the gut absorb calcium. In fracture trials the result depends on the combination: a Cochrane review of 53 trials found that vitamin D alone was unlikely to prevent hip fracture or any new fracture, while vitamin D plus calcium gave a small reduction in hip fractures. In VITAL, vitamin D3 alone did not significantly lower fractures or major cardiovascular events in 25,871 adults who were not selected for low vitamin D. Calcium with vitamin D has also been linked to more kidney stones, and vitamin D supplements to more high blood calcium.
Vitamin K2 (MK-7)
Researchers have proposed that vitamin K2 helps activate proteins (osteocalcin and matrix Gla protein) involved in how calcium is handled in bone and artery walls. A 2026 review describes this as plausible but insufficiently confirmed in humans, and found no adequately powered trial showing that vitamin D3 with MK-7 is better than its components or placebo for any clinical outcome. Human trials of MK-7 on bone and arterial calcification have been mixed (see below), and they measured bone density and scan scores, not fractures or heart attacks.
Note: Vitamin K2 (MK-7) can interfere with warfarin and similar vitamin K antagonist medicines. In a study of healthy volunteers taking acenocoumarol, 45 µg a day of MK-7 lowered the INR by about 40%, and the authors concluded that MK-7 supplements need to be avoided in people on vitamin K antagonist therapy. Ask your prescriber or pharmacist before use.
BioPerine® Black Pepper Extract
The supplier lists BioPerine® as a black pepper fruit extract. No study of its effect on the absorption of vitamin D or vitamin K is cited on this page.
What the research says
- A Cochrane review of 53 trials found vitamin D alone unlikely to prevent hip or other fractures, while vitamin D plus calcium gave a small reduction in hip fractures (risk ratio 0.84) (Avenell et al., 2014, Cochrane Database of Systematic Reviews).
- In VITAL (25,871 adults), vitamin D3 2,000 IU a day, the dose tested in that trial, did not lower the risk of major cardiovascular events (hazard ratio 0.97) or invasive cancer (0.96) (Manson et al., 2019, New England Journal of Medicine).
- In a 3-year trial of 244 healthy postmenopausal women, MK-7 at 180 µg a day, the dose tested in that trial, reduced bone loss at the lumbar spine and femoral neck but not at the total hip (Knapen et al., 2013, Osteoporosis International).
- Trials of MK-7 with vitamin D on arterial calcification are mixed: no effect on aortic valve calcification in men (Diederichsen et al., 2022, Circulation), and slower progression of coronary calcification scores in people with severe calcification (Hasific et al., 2026, Circulation).
- Long-term vitamin D supplementation increased high blood calcium (relative risk 1.54) and high urinary calcium (1.64) in a meta-analysis of 48 studies (Malihi et al., 2016, American Journal of Clinical Nutrition), and calcium with vitamin D increased kidney stones in the Women's Health Initiative trial (Jackson et al., 2006, New England Journal of Medicine).
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
| Product Details |
| Form |
Vegetable capsule (cellulose) |
| Servings |
60 (60 capsules) |
| Manufactured in |
USA |
| Net weight |
0.25 lb (113 g) |
Full Ingredient List: Calcium (as Calcium Carbonate), Vitamin D3 (Cholecalciferol), Vitamin K2 MK-7 (as Menaquinone), BioPerine® Black Pepper Fruit Extract, Cellulose (vegetable capsule)
Suggested Use
Take 1 capsule daily as a dietary supplement.
Note: one capsule is one serving and provides 125 mcg (5,000 IU) of vitamin D3, 100 mcg of vitamin K2, 210 mg of calcium and 5 mg of BioPerine®. At 1 capsule daily, a 60-capsule bottle lasts 60 days. The vitamin D3 in one capsule is above the adult Tolerable Upper Intake Level of 100 mcg (4,000 IU) a day from all sources set by the US National Academy of Medicine. Ask a doctor or pharmacist before use, count vitamin D and calcium from any other supplements, and do not combine this product with other vitamin D products.
Cautions & Warnings
- Do not exceed the recommended dose.
- Consult a physician before use if you are pregnant, nursing, under 18, or have a known medical condition — particularly if you take blood-thinning medications (e.g., warfarin), as vitamin K2 may interact with anticoagulant therapy.
- Keep out of reach of children.
- Do not use if the safety seal is damaged or missing.
- Store in a cool, dry place away from direct sunlight and moisture.
Frequently Asked Questions
What does Vitamin D3 with K2 do? Vitamin D helps the gut absorb calcium, and vitamin K2 helps activate proteins involved in how calcium is handled in bone and artery walls. Whether adding K2 to vitamin D improves bone or heart outcomes has not been established, and trials so far have been mixed.
How should it be taken? Take 1 capsule daily. One capsule provides 125 mcg (5,000 IU) of vitamin D3, which is above the 4,000 IU a day adult upper intake level from all sources, so ask a doctor or pharmacist before use and do not combine it with other vitamin D products.
Does this product contain calcium? Yes. One capsule provides 210 mg of calcium (as calcium carbonate), 16% of the Daily Value. In the Women's Health Initiative, 1,000 mg of calcium with 400 IU of vitamin D3 a day was associated with more kidney stones (hazard ratio 1.17). Ask a doctor first if you have kidney stones, kidney disease or high blood calcium.
What is MK-7 vitamin K2? MK-7 (menaquinone-7) is one form of vitamin K2, and the supplier lists it as Vitamin K2 MK-7 (as Menaquinone). The 3-year bone trial in postmenopausal women used 180 µg a day of MK-7; this page does not state the amount in each capsule. MK-7 can interfere with warfarin and similar medicines.
What is BioPerine® used for? BioPerine® is the trade name of the black pepper fruit extract listed in the ingredients. No study of its effect on vitamin D or vitamin K absorption is cited on this page.
Is this product vegetarian or vegan? The capsule shell is hypromellose (vegetable capsule) and no gelatin is listed on the label. The source of the vitamin D3 is not stated on this page, so suitability for vegans is unconfirmed.
Who should talk to a doctor or pharmacist before taking D3 + K2? Speak with a doctor or pharmacist first if you take warfarin or another blood thinner, a thiazide diuretic or other prescribed medicines; if you have kidney disease, kidney stones, high blood calcium, an overactive parathyroid gland, sarcoidosis or heart disease; if you are pregnant, breastfeeding or under 18; or if you already take other vitamin D or calcium supplements. Never stop or change a prescribed medicine without asking your prescriber.
Science behind this product
Vitamin D and Calcium for Fractures
A Cochrane review of 53 trials (91,791 participants) found that vitamin D alone was unlikely to prevent hip fracture or any new fracture, while vitamin D plus calcium gave a small reduction in hip fractures (risk ratio 0.84) and in any fracture (0.95). Source In VITAL, vitamin D3 2,000 IU a day did not significantly reduce total fractures (hazard ratio 0.98) in 25,871 adults who were not selected for low vitamin D, bone loss or osteoporosis. Source
Vitamin K2 (MK-7) and Bone Mineral Density
In a 3-year trial of 244 healthy postmenopausal women, 180 µg a day of MK-7 reduced the age-related decline in bone mineral density at the lumbar spine and femoral neck, but not at the total hip. The trial measured bone density and strength indices, not hip fractures. Source
Vitamin K2, Vitamin D and Vascular Calcification
In 365 men with aortic valve calcification, 2 years of MK-7 (720 µg a day) with vitamin D did not slow progression of aortic valve calcification. Source In a 2026 trial of 398 people with severe coronary artery calcification, the same type of combination slowed progression of the calcification score (mean increase 196 vs 248 units over 24 months). Source A trial in 60 children on hemodialysis found that MK-7 (100 µg) with vitamin D (10 µg) lowered blood levels of some calcification-regulating proteins more than the other groups after 4 months. Source These trials measured scan scores or blood markers, not heart attacks or deaths, and used doses that may differ from this product.
Evidence Rating★★★★★Limited and mixed evidence · Vitamin D with calcium had a small effect on fractures; vitamin D alone did not prevent fractures or cardiovascular events in VITAL; K2 trials on bone and arterial calcification are mixed; no study of this product is cited
✓ Third-party tested · GMP-certified manufacturing facility (NSF International) · See testing standards ›
