Kasivit

Kasivit Berberine Capsules - 60 Count

Name: Kasivit Berberine Capsules - 60 Count
Brand: Kasivit
SKU: JTP4BERB
Price: 34.9 USD
Availability: InStock

Berberine hydrochloride extract capsules (97% and 8% extracts), 60 vegan capsules. Berberine can interact with prescription medicines and is not a substitute for diabetes medicine: ask your prescriber or pharmacist.

💊Adults: take two (2) capsules daily with 6-8 oz (177-236 ml) of water, or as directed by a healthcare professional. Do not exceed the recommended dose.

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Key Benefits

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Two Berberine Hydrochloride Extracts

Contains berberine hydrochloride extracts standardized to 97% (bark) and 8% (bark/root). Berberine is a plant alkaloid studied mainly in adults with type 2 diabetes, metabolic syndrome or raised blood fats. The berberine content per serving is not confirmed on this page, and no study of this product is cited.

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Blood Sugar: Modest Effect in Trials

In a meta-analysis of 37 randomized trials (3,048 people with type 2 diabetes), berberine lowered HbA1c by about 0.63 percentage points and fasting glucose by about 0.82 mmol/L compared with control. A separate meta-analysis of 27 trials found no statistically significant difference between berberine and oral glucose-lowering drugs. Berberine is not a substitute for diabetes medicine.

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Blood Fats and Body Weight: Small Effects

In a meta-analysis of 41 trials, products containing berberine lowered LDL cholesterol by about 15 mg/dL, but berberine alone did not lower LDL significantly (berberine alone lowered triglycerides by about 17 mg/dL); results varied widely between trials. In a meta-analysis of 23 trials, body weight was about 0.9 kg lower than with control. Berberine is not a weight-loss treatment.

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Digestive Effects Were Reported in Trials

In a small pilot study, 20 patients (34.5%) had temporary digestive side effects. In a placebo-controlled trial of 116 people, five berberine-treated participants had mild to moderate constipation. Tell a healthcare provider about any side effects.

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Medicine Interactions and Pregnancy

In healthy volunteers, two weeks of berberine reduced the activity of CYP2D6, CYP2C9 and CYP3A4, enzymes that break down many medicines. In kidney-transplant recipients it was associated with higher cyclosporine levels. It lowers blood glucose and can add to diabetes medicines. Rare cases of torsades de pointes, a heart-rhythm problem, have been reported. Avoid it in pregnancy and breastfeeding. Ask your prescriber or pharmacist before use.

✅This product is for you if…

Adults who have talked with a doctor or pharmacist about berberine and want a berberine hydrochloride extract in a vegetable capsule
Adults who understand that berberine is not a substitute for diabetes, cholesterol or blood-pressure medicine and who have checked their medicines for interactions
Adults who prefer a gluten-free, vegan capsule (per the supplier)

⚠️Consult your healthcare provider if…

You are pregnant or breastfeeding, or the person is a child or under 18: avoid berberine (laboratory and rat studies suggest it displaces bilirubin; the supplier warning also advises these groups to consult a physician)
You take diabetes medicines or insulin: berberine lowers blood glucose and the effects may add up; ask your prescriber or pharmacist first and do not use berberine in place of diabetes medicine
You take cyclosporine or other immunosuppressants: berberine was associated with higher cyclosporine levels in kidney-transplant recipients; ask your prescriber or pharmacist first
You take other prescription medicines, especially medicines processed by CYP2D6, CYP2C9 or CYP3A4 or medicines with a narrow safety margin: berberine reduced the activity of these enzymes in healthy volunteers; ask your pharmacist to review them
You take cholesterol, blood-pressure or heart-rhythm medicines, or medicines that affect heart rhythm, or you have a heart-rhythm condition or low magnesium: rare cases of torsades de pointes have been reported with berberine; speak with your doctor first
You have kidney or liver disease: safety in these conditions has not been adequately studied; ask your healthcare provider before use
You have G6PD deficiency, or the person is a newborn or infant: berberine-containing herbs have been linked in some reports to jaundice in newborns; evidence is conflicting; ask a doctor
You have surgery planned: berberine lowers blood glucose and can interact with medicines; tell your doctor you take it
Never stop or change a prescribed medicine because of a supplement; ask your prescriber

Formula

Ingredients & Dosages

Serving size: Adults: take two (2) capsules daily with 6-8 oz (177-236 ml) of water, or as directed by a healthcare professional. Do not exceed the recommended dose.

Ingredient	Amount Per Serving	Purpose
Granular Berberine Hydrochloride Extract 8% (bark/root)	790 mg	Broad-spectrum berberine alkaloid complex from whole bark and root
Granular Berberine Hydrochloride Extract 97% (bark)	10 mg	High-purity standardized berberine HCL

† Daily Value not established. Other ingredients: Cellulose (vegetable capsule), MCC (microcrystalline cellulose), L-Leucine, Olive Oil.

Science

Clinical Evidence

Published research relevant to this product. These studies were generally not conducted on this specific product.

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In a meta-analysis of 37 randomized trials (3,048 people with type 2 diabetes), berberine lowered HbA1c by about 0.63 percentage points and fasting glucose by about 0.82 mmol/L compared with control; the authors reported no significant increase in the risk of hypoglycaemia (relative risk 0.48, 95% CI 0.21 to 1.08) in trials of berberine alone or with oral glucose-lowering drugs

Xie W et al. Front Pharmacol. 2022;13:1015045. ↗

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A meta-analysis of 27 randomized trials (2,569 people) found that berberine with lifestyle changes tended to lower fasting glucose, post-meal glucose and HbA1c more than lifestyle changes alone or placebo, but there was no statistically significant difference between berberine and oral glucose-lowering drugs

Lan J et al. J Ethnopharmacol. 2015;161:69-81. ↗

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In a pilot study, 36 adults with newly diagnosed type 2 diabetes were randomised to berberine or metformin (0.5 g three times a day) for 3 months and the authors described the glucose-lowering effect of berberine as similar to that of metformin (HbA1c fell from 9.5% to 7.5% with berberine); across the pilot, 20 patients (34.5%) had transient gastrointestinal side effects. The study was small

Yin J et al. Metabolism. 2008;57(5):712-717. ↗

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In 116 people with type 2 diabetes and abnormal blood fats, berberine (1.0 g a day) for 3 months lowered fasting glucose, HbA1c, triglycerides and LDL cholesterol compared with placebo; mild to moderate constipation occurred in five participants taking berberine

Zhang Y et al. J Clin Endocrinol Metab. 2008;93(7):2559-2565. ↗

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A meta-analysis of 41 randomized trials (4,838 people, 8 to 18 weeks) found that berberine-containing products lowered LDL cholesterol by about 15 mg/dL and triglycerides by about 19 mg/dL versus control, with high variation between trials; for berberine alone the LDL change (-9.26 mg/dL) was not statistically significant, while triglycerides fell by about 17 mg/dL

Hernandez AV et al. J Diet Suppl. 2024;21(2):242-259. ↗

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In a meta-analysis of placebo-controlled trials in people with metabolic syndrome, berberine lowered triglycerides, fasting plasma glucose and waist circumference but did not significantly change HDL cholesterol or blood pressure; the authors called for more high-quality trials

Liu D et al. Front Pharmacol. 2025;16:1572197. ↗

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A meta-analysis of 23 articles found that berberine reduced body weight by about 0.88 kg (95% CI 0.39 to 1.36) and BMI by about 0.48 kg/m2 compared with control; the authors recommended better reporting of the purity, potency and gram amounts of the berberine used and noted common biases such as lack of blinding and randomization

Elahi Vahed et al. Int J Obes (Lond). 2026;50(1):53-73. ↗

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In a double-blind trial of berberine 0.3 g twice daily versus placebo in people who had colorectal adenomas removed, the most common adverse event was constipation (1% with berberine versus under 0.5% with placebo) and no serious adverse events were reported

Chen YX et al. Lancet Gastroenterol Hepatol. 2020;5(3):267-275. ↗

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In healthy men, two weeks of berberine (300 mg three times a day) decreased the activity of the liver enzymes CYP2D6, CYP2C9 and CYP3A4 (midazolam exposure rose by about 40%); the authors advised that drug-drug interactions should be considered

Guo Y et al. Eur J Clin Pharmacol. 2012;68(2):213-217. ↗

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In 52 kidney-transplant recipients taking cyclosporine with berberine (0.2 g three times daily for 3 months), blood trough levels of cyclosporine were about 29% higher than in 52 patients not taking berberine, and in a small pharmacokinetic study (6 patients) cyclosporine exposure rose by about 35%

Wu X et al. Eur J Clin Pharmacol. 2005;61(8):567-572. ↗

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A 2026 narrative review concluded that berberine, despite very low blood levels, can interact with medicines through CYP3A4, CYP2D6 and CYP2C9 and transporters and through additive effects (low blood glucose, low blood pressure, QT prolongation), and should be managed as an active pharmacological agent rather than an inert supplement, particularly with medicines that have a narrow safety margin

Dumitru CN et al. Pharmaceuticals (Basel). 2026;19(8):1313. ↗

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Case report: a 61-year-old man taking several supplements including berberine and dihydroberberine, with mild low magnesium, had recurrent torsades de pointes (QTc 669 ms); the QT interval normalized after the supplements were stopped and other treatment was given. A case report cannot show that berberine was the cause

Mohammadi A et al. JACC Case Rep. 2026:110193. ↗

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Case report: a 36-year-old woman who had taken berberine for several months had a prolonged QT interval and a cardiac arrest from torsades de pointes; her symptoms and ECG abnormalities resolved completely after berberine was stopped

Williams JM et al. Cureus. 2026;18(6):e111276. ↗

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Case report: a 92-year-old man developed repeated episodes of torsades de pointes (QTc 616 ms) about two weeks after starting berberine; the QTc improved after berberine was withheld

Mesmin MP et al. Clin Pract Cases Emerg Med. 2026;10(3):392-394. ↗

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In laboratory and rat experiments berberine displaced bilirubin from its carrier protein in the blood, and the author advised that berberine-rich herbs be avoided in jaundiced newborns and pregnant women (this was not a study in pregnant women)

Chan E. Biol Neonate. 1993;63(4):201-208. ↗

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Two berberine-containing herbs are banned in Singapore because berberine was implicated in aggravating jaundice and kernicterus in newborns with G6PD deficiency; the authors' literature review found conflicting evidence for and against this

Linn YC et al. Phytother Res. 2012;26(5):682-686. ↗

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A 2026 toxicology review of Berberis plants and their alkaloids (145 studies) reported toxic effects involving the liver, kidney, cardiovascular and immune systems and embryonic development under specific doses, routes of administration or individual conditions

Ma J et al. Phytomedicine. 2026;162:158782. ↗

🔬 All studies referenced are peer-reviewed and published in indexed medical journals. This information is for educational purposes and does not constitute medical advice.

Berberine hydrochloride extracts (97% and 8%) in a vegetable capsule
Gluten free and vegan, per the supplier
Suggested use: 2 capsules daily; 60 capsules
Can interact with prescription medicines and is not a substitute for diabetes medicine: ask your prescriber or pharmacist first

Kasivit Berberine is a dietary supplement made with two berberine hydrochloride extracts (97% and 8%), taken as 2 capsules daily according to the supplier's suggested use. Berberine is a plant alkaloid that has been studied mainly in adults with type 2 diabetes, metabolic syndrome or raised blood fats. In a meta-analysis of 37 randomized trials in type 2 diabetes, berberine lowered HbA1c by about 0.6 percentage points compared with control, but most trials were small and of limited quality. Several of the trials used about 1,000 to 1,500 mg of berberine a day, and the berberine content of one serving of this product is not confirmed on this page, so the trial results should not be assumed to apply to it. No study of Kasivit Berberine itself is cited.*

Berberine is not a substitute for diabetes medicine or cholesterol medicine, and it is not a weight-loss treatment: in a meta-analysis of 23 trials, body weight was about 0.9 kg lower than with control. Digestive side effects such as constipation were the most commonly reported in trials. Berberine lowers blood glucose and can add to the effect of diabetes medicines. In healthy volunteers it reduced the activity of liver enzymes that break down many medicines (CYP2D6, CYP2C9 and CYP3A4), and in kidney-transplant recipients it was associated with higher blood levels of cyclosporine. Rare cases of a dangerous heart-rhythm problem (torsades de pointes) have been reported in people taking berberine. Avoid it in pregnancy and breastfeeding. Ask your prescriber or pharmacist before use if you take any prescription medicine.*

A healthy, active lifestyle with balanced nutrition and regular exercise remains the foundation of metabolic health, and berberine is not a substitute for it.

Evidence Rating★★★★★Limited evidence · Pooled trials show modest effects on blood sugar and blood fats, but most trials are small and of limited quality; no study of this product is cited

✓ Third-party tested · GMP-certified manufacturing facility (UL Solutions) · See testing standards ›

Ingredients: Granular Berberine Hydrochloride Extract 97% (bark), Granular Berberine Hydrochloride Extract 8% (bark/root), Cellulose (vegetable capsule), MCC (microcrystalline cellulose), L-Leucine, Olive Oil.

Manufacturer's country: USA

Product amount: 60 capsules

Gross weight (lb/g): 0.2 lb / 90 g

Suggested use: As a dietary supplement, adults take two (2) capsules daily. For best results, take with 6-8 oz (177-236ml) of water or as directed by healthcare professional.

Warning: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with known medical conditions should consult a physician before using this or any dietary supplement. KEEP OUT OF THE REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Gluten-free Vegetarian Allergen-free Non-GMO Vegan friendly