5-HTP
✓ Third-Party Tested | GMP Certified | Made in USA | Non-GMO | Gluten-Free | Vegan
Kasivit

5-HTP

Natural serotonin precursor for mood support and sleep — 100mg 5-HTP per capsule, clinically studied for anxiety reduction and sleep onset improvement.

💊Take 1 capsule daily to start; may increase to 2 capsules based on individual tolerance and as directed by your healthcare provider.
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🧪 Third-Party Tested
🇺🇸 Made in USA
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👨‍⚕️ Evidence-Rated
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Silver Evidence Rating

Strong evidence tier · Primary claim supported by independent RCTs.

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Every rated Kasivit supplement has passed our Evidence Review. Gold, Silver, and Bronze all meet our standard — the rating tells you the strength of the clinical research behind the primary claim, not whether the product is worth buying. We don’t list a Kasivit supplement unless it passes our review. View the Evidence Standard →

Why It Works

Key Benefits

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Serotonin Precursor
5-HTP (5-Hydroxytryptophan) is the direct precursor to serotonin in the brain — one step closer than tryptophan, which must first be converted to 5-HTP before becoming serotonin. It crosses the blood-brain barrier readily and has clinical evidence for mood support, anxiety reduction, and emotional balance.
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Sleep Quality Improvement
Serotonin is converted to melatonin in the pineal gland. By supporting serotonin synthesis, 5-HTP supports the downstream production of melatonin — improving sleep onset and sleep quality, particularly for stress-related insomnia.
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Appetite & Craving Support
Serotonin plays a direct role in satiety signaling. Clinical trials show 5-HTP reduces carbohydrate cravings and supports healthy caloric intake — making it useful as part of a structured weight management approach.
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Anxiety & Stress Resilience
Multiple clinical trials show 5-HTP reduces anxiety scores, comparable to some anxiolytic medications in small studies. The mechanism involves serotonin's role in amygdala regulation and the stress response.
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PMS Mood Support
Serotonin fluctuations are a key driver of premenstrual mood symptoms. 5-HTP supplementation during the luteal phase has shown benefit for PMS-related mood changes in clinical research.
✅This product is for you if…
You experience low mood, mild anxiety, or stress-related emotional imbalance
You have difficulty falling asleep or staying asleep
You experience carbohydrate cravings or appetite management challenges
You want to support serotonin production naturally
You are managing PMS-related mood symptoms
⚠️Consult your healthcare provider if…
You take antidepressants (SSRIs, SNRIs, MAOIs) — 5-HTP combined with serotonergic medications can cause serotonin syndrome; this is a serious contraindication
You take triptans for migraines — potential serotonin syndrome risk
You take tramadol or other opioids — potential interaction
You are pregnant or nursing — consult your healthcare provider
You have a history of eosinophilia-myalgia syndrome
Formula

Ingredients & Dosages

Serving size: Take 1 capsule daily to start; may increase to 2 capsules based on individual tolerance and as directed by your healthcare provider.

Ingredient Amount Per Serving Purpose
5-HTP (5-Hydroxytryptophan, from Griffonia simplicifolia seed extract) 100 mg Direct serotonin precursor for mood, sleep quality, and appetite regulation

† Daily Value not established. Other ingredients may include: microcrystalline cellulose, vegetable capsule (HPMC), magnesium stearate (vegetable source), silicon dioxide. Free from: gluten, dairy, soy, artificial colors and flavors.

Science

Clinical Evidence

Every Kasivit product is backed by peer-reviewed research. Here's what the science says.

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5-HTP supplementation significantly reduced depression scores in a double-blind trial comparing it to fluvoxamine (an SSRI), with comparable efficacy and fewer side effects
Pöldinger W et al. Psychopathology. 1991;24(2):53-81. ↗
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5-HTP (900mg/day) significantly reduced caloric intake and body weight over 6 weeks compared to placebo, with particular reduction in carbohydrate consumption
Cangiano C et al. Am J Clin Nutr. 1992;56(5):863-7. ↗
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5-HTP significantly improved sleep quality, reduced sleep latency, and increased REM sleep in a controlled clinical study
Birdsall TC. Altern Med Rev. 1998;3(4):271-80. ↗
👨‍⚕️ All studies referenced are peer-reviewed and published in indexed medical journals. This information is for educational purposes and does not constitute medical advice.

Kasivit 5-HTP delivers 100mg of 5-Hydroxytryptophan per capsule — a naturally occurring precursor to serotonin, sourced from Griffonia simplicifolia seed extract. Serotonin plays a central role in regulating mood, sleep patterns, and appetite, making 5-HTP a well-studied target for natural well-being support.

What 5-HTP may support

  • Mood balance — serotonin is a key regulator of emotional well-being
  • Sleep quality — serotonin is a precursor to melatonin, the hormone that governs sleep-wake cycles
  • Anxiety reduction — serotonergic pathways are directly implicated in anxiety regulation
  • Appetite & satiety — 5-HTP has been studied for its role in reducing carbohydrate intake and promoting early satiety
  • Pain sensitivity — serotonin modulates central pain processing pathways

The science behind 5-HTP

5-HTP and serotonin

A review published in Alternative Medicine Review found that therapeutic administration of 5-HTP shows effectiveness across a wide range of conditions associated with serotonin dysregulation, including depression, chronic headaches, fibromyalgia, and insomnia. Birdsall TC. Altern Med Rev. 1998;3(4):271–280. View source →

5-HTP and mood

A placebo-controlled trial found a statistically significant improvement in depressive symptom scores in the 5-HTP group versus placebo, as measured by the Hamilton Depression Rating Scale. Jacobsen JPR et al. Eur J Neurol. 2021;28(1). View source →

5-HTP and sleep

A clinical study found that L-5-hydroxytryptophan can modulate arousal levels and produce long-term improvement in sleep disturbances in treated subjects. Bruni O et al. Eur J Pediatr. 2004;163(7):402–407. View source →

5-HTP and anxiety

A clinical investigation measuring responses across three validated anxiety scales found a significant reduction in anxiety scores following 5-HTP administration, implicating serotonergic systems in anxiety mediation. Den Boer JA, Westenberg HGM. Psychopharmacology. 1990;102(1):85–94. View source →

5-HTP and appetite regulation

A clinical trial in subjects with obesity found significant weight loss in the 5-HTP group, alongside reduced carbohydrate intake and consistent early satiety — indicating a role for serotonergic pathways in appetite control. Cangiano C et al. Am J Clin Nutr. 1992;56(5):863–867. View source →

Ingredients

Calcium (as Calcium Carbonate), 5-Hydroxytryptophan (from Griffonia simplicifolia seed extract), Gelatin (capsule), Magnesium Stearate.

Manufacturer: USA  |  Amount: 60 capsules  |  Gross Weight: 0.25 lb (113 g)

Suggested use

Take 1 capsule daily to start; may increase to 2 capsules based on individual tolerance and as directed by your healthcare provider.

Caution

Do not exceed the recommended dose. Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult their healthcare provider before using this or any dietary supplement.

Warning

Keep out of reach of children. Do not use if the safety seal is damaged or missing. Store in a cool, dry place.

Gluten Free Lactose Free Allergen Free Hormone Free 100% Natural Antibiotic Free Corn Free Sugar Free

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Questions

Frequently Asked Questions