Welcome to Issue 01 of The Kasivit Journal.
We started The Kasivit Journal because the gap between what clinical research shows and what most people hear about supplements is enormous. Too much supplement advice is vague, overstated, or untethered from evidence. Every issue, we aim to close that gap — clearly, honestly, and without an agenda beyond helping you make better decisions.
GLP-1 medications like Ozempic and Wegovy represent a genuine advance in metabolic medicine. They also create nutritional vulnerabilities that most patients — and many clinicians — aren't aware of. This issue is largely about that.
— The Kasivit Editorial Team
The gut lining is a single cell layer thick. L-Glutamine is the primary fuel source for intestinal epithelial cells, and clinical evidence supports its role in maintaining tight junction integrity — particularly relevant for GLP-1 users whose altered gastric motility changes the gut environment.
Read the full article →Melatonin signals your body it's nighttime but doesn't improve sleep architecture. Magnesium glycinate modulates GABA receptors and reduces cortisol, actually improving deep sleep quality.
Read the full article →GLP-1 medications suppress appetite dramatically, but nutritional needs don't shrink with appetite. Six supplements — each addressing a specific vulnerability — are consistently supported by the evidence.
Read the full article →Berberine improves insulin sensitivity and fasting glucose via the AMPK pathway — the same energy-sensing mechanism that GLP-1 receptor agonists activate through a different route. Complementary mechanisms, additive metabolic benefits, no pharmacological conflict.
Patients on semaglutide showed significant microbiome shifts at 12 weeks. Those who supplemented with probiotics during treatment showed smaller disruption and fewer GI side effects.
Magnesium is involved in over 300 enzymatic reactions. Nearly half of Americans are functionally deficient — and reduced food intake on GLP-1 therapy compounds this further. Magnesium glycinate is the chelated form with documented superior bioavailability compared to magnesium oxide, which provides less than 4% absorption and commonly causes GI distress.
Bedtime dosing is recommended: it supports sleep architecture and overnight muscle recovery — both of which are particularly important during periods of active weight loss.
Shop Magnesium Glycinate →Protein distribution matters as much as total protein. Spreading intake evenly across meals improved lean mass retention during caloric restriction. JAMA Internal Medicine, 2024.
Creatine preserves muscle during semaglutide treatment. 5 g/day creatine monohydrate significantly attenuated lean mass loss vs. placebo over 24 weeks. Obesity, 2025.
Magnesium deficiency is underdiagnosed. Only 1% of body magnesium is in the blood; serum levels appear normal while cellular stores are depleted. An estimated 45% of Americans are functionally deficient. Nutrients, 2023.
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